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Image Search Results
Journal: BMC Pulmonary Medicine
Article Title: Metformin attenuates lung ischemia-reperfusion injury and necroptosis through AMPK pathway in type 2 diabetic recipient rats
doi: 10.1186/s12890-024-03056-z
Figure Lengend Snippet: Metformin reduced the inflammatory response in type 2 diabetic lung transplant recipient rats. ( A ) IL-1β concentration in serum ( n = 8). ( B ) IL-6 concentration in serum ( n = 8). ( C ) TNF-α concentration in serum ( n = 8). ( D ) IL-10 concentration in serum ( n = 8). ( E ) IL-1β concentration in BALF ( n = 4). ( F ) IL-6 concentration in BALF ( n = 4). ( G ) TNF-α concentration in BALF ( n = 4). (H) IL-10 concentration in BALF ( n = 4). (I) MPO activity in lung grafts ( n = 6). Compared with CS group, * P <0.05; compared with CIR group, # P <0.05; compared with DS group, & P <0.05; compared with DIR group, ^ P <0.05; compared with DIRM group, v P <0.05
Article Snippet: The interleukin (IL)-1β (No.JM-01454R1, Jingmei Biotechnology), IL-6 (No.JM-01597R1, Jingmei Biotechnology), tumor necrosis factor-α (TNFα) (No.JM-01587R1, Jingmei Biotechnology) and
Techniques: Concentration Assay, Activity Assay
Journal: Biomedicines
Article Title: Discovery through Machine Learning and Preclinical Validation of Novel Anti-Diabetic Peptides
doi: 10.3390/biomedicines9030276
Figure Lengend Snippet: In vitro validation of predicted peptides as potent stimulators of glucose uptake and Glucose transporter type 4 (GLUT4) translocation. Skeletal muscle cells were stimulated with either insulin or predicted natural peptides at the indicated concentrations for 15 min. ( A ) The effect on glucose uptake is measured, while in ( B ), the extent of GLUT4 translocation is assessed (one-way ANOVA analysis with Dunnett’s test; *** p < 0.001; data presented are the mean ± SEM of at least 3 independent replicates).
Article Snippet: GLUT4 concentration was subsequently measured via a commercially available
Techniques: In Vitro, Biomarker Discovery, Translocation Assay